Exercise training in childhood cancer : A systematic review and meta-analysis of randomized controlled trials
| Autor: | Carmen Fiuza-Luces, Javier S. Morales, Pedro L. Valenzuela, Cecilia Rincón-Castanedo, Alejandro Lucia, Alejandro Santos-Lozano, Tim Takken |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Pediatric cancer Psychological intervention law.invention 03 medical and health sciences 0302 clinical medicine Quality of life Randomized controlled trial law Neoplasms Fitness Humans Medicine Radiology Nuclear Medicine and imaging Mortality Child Adverse effect Exercise Randomized Controlled Trials as Topic business.industry Pediatría Cancer 030229 sport sciences General Medicine Odds ratio Deporte Cáncer medicine.disease Ejercicio físico Cáncer en niños Functional mobility Oncology Radiology Nuclear Medicine and imaging 030220 oncology & carcinogenesis Meta-analysis Quality of Life Physical therapy business |
| Zdroj: | Cancer Treatment Reviews, 70, 154. W.B. Saunders Ltd |
| ISSN: | 0305-7372 |
| Popis: | Introduction Physical capacity and quality of life (QoL) are typically impaired in children/adolescents with cancer. Our primary objective was to examine the effects of exercise training performed after diagnosis of any type of pediatric cancer on physical capacity-related endpoints, survival, disease relapse and adverse effects. Methods (a) Search and selection criteria: Systematic review in Pubmed and Web of Science (until August 2018) of randomized controlled trials (RCTs) of exercise interventions in children with cancer during treatment or within one year after its end. (b) Data collection: Two authors independently identified studies meeting inclusion criteria, extracted data, and assessed risk of bias using standardized forms. When needed, we contacted authors to request clarifications or additional data. (c) Statistical Analysis: The pooled standardized mean differences (SMD) were calculated for those endpoints for which a minimum of three RCTs used the same assessment method. We also calculated the pooled odds ratio (OR) of dying or having a tumor relapse. Results Eight RCTs (n = 283 patients) were included in the systematic review. Of these, five studies (n = 173) could be meta-analyzed. Exercise training during pediatric cancer treatment significantly improves patients’ functional mobility, as assessed with the timed up and down stairs test (SMD: −0.73, p |
| Databáze: | OpenAIRE |
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