The validity of the acute stroke assessment using rapid pseudo-continuous arterial spin labeling (ASAP-ASL) method for acute thrombectomy
| Autor: | Yoshimasa Niiya, Shoji Mabuchi, Shipei Satoh, Motoyuki Iwasaki, Masahito Kawabori, Daisuke Oura, Takumi Yokohama, Kiyohiro Houkin |
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| Rok vydání: | 2018 |
| Předmět: |
Perfusion scanning
050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Occlusion medicine Humans 0501 psychology and cognitive sciences Cerebral perfusion pressure Thrombectomy medicine.diagnostic_test business.industry Penumbra 05 social sciences Brain Magnetic resonance imaging Digital subtraction angiography Magnetic Resonance Imaging Clinical trial Stroke Signal-to-noise ratio (imaging) Cerebrovascular Circulation Surgery Spin Labels Neurology (clinical) Nuclear medicine business 030217 neurology & neurosurgery Magnetic Resonance Angiography |
| Zdroj: | Journal of neurosurgical sciences. 65(5) |
| ISSN: | 1827-1855 |
| Popis: | BACKGROUND Recent clinical trials demonstrated the efficacy of thrombectomy for ischemic stroke against acute large vessel occlusion (LVO). To overcome the problem with excessive examination time for diagnosis of cerebral perfusion and/or the use of contrast agent to determine penumbra, we adopted a new magnetic resonance imaging technique named Acute Stroke Assessment using rapid Pseudo-continuous arterial spin labeling (ASAP-ASL) method. METHODS The study included healthy volunteers and clinical patients. The signal to noise ratio (SNR) and acquisition time were compared with various numbers of signal average (NSA) of rapid pseudo-continuous arterial spin labeling (pCASL) using the 10-mm thick slice width and narrow scan range focusing the level of basal ganglia by healthy volunteers. After applying clinically acceptable protocol for ASAP-ASL, we then checked image qualities and an accuracy of the method by comparing with the angiographical imaging obtained from the clinical patients regarding the degree of consistency. RESULTS NSA were compared between two and fourteen, and 10 NSA was decided to be introduced for clinical use (1 minutes and 17 second) for obtaining clinically acceptable image, which was shorter than the time required for ordinary whole brain pCASL (approximately 5 minutes). In the clinical study, the occlusion site estimated by ASAP-ASL showed high correlation with that of digital subtraction angiography (κ=0.63-0.79). CONCLUSIONS ASAP-ASL method requires approximately one minutes to obtain clinically relevant brain perfusion imaging which can successfully identify ischemic region in LVO patients. |
| Databáze: | OpenAIRE |
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