Running-induced Functional Mobility Improvement in the Elderly Males is Driven by Enhanced Plasma BDNF Levels and the Modulation of Global Histone H4 Acetylation Status
| Autor: | Gustavo Pereira Reinaldo, Anelise Ineu Figueiredo, Viviane Rostirola Elsner, Joao Jose Cunha, Ivy Reichert Vital da Silva, Maristela Padilha de Souza, Andreia Bard, Laura Luna Martins |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Brain-derived neurotrophic factor
medicine.medical_specialty sed business.industry Rehabilitation lcsh:RM1-950 Physical Therapy Sports Therapy and Rehabilitation Histone H4 03 medical and health sciences 0302 clinical medicine Endocrinology lcsh:Therapeutics. Pharmacology Neurotrophic factors Internal medicine medicine Biomarker (medicine) 030212 general & internal medicine Epigenetics business computer 030217 neurology & neurosurgery Epigenomics computer.programming_language Whole blood |
| Zdroj: | Middle East Journal of Rehabilitation and Health, Vol 4, Iss 3 (2017) |
| ISSN: | 2423-4451 |
| Popis: | Background Emerging evidence point out that exercise is an epigenetic modulator and is able to alter brain-derived neurotrophic factor (BDNF) levels in different populations. However, little is known about the impact of exercise on these markers in well-trained aged individuals, making this research topic particularly relevant. Objectives Therefore, the current study aimed at investigating the impact of the regular running practice on global histone H4 acetylation and brain–derived neurotrophic factor (BDNF) levels as well as on the functional mobility in healthy elderly males. Methods Fifteen male volunteers aged 60 years and older were recruited. They were allocated into 2 groups: runners (RUN, n = 8) and sedentary (SED, n = 7), taking into account the question that they were sedentary or amateur street runners. Whole blood samples (15 mL) were collected for the biochemical measurements and the functional mobility assessment was performed through the timed up and go (TUG) test. The biochemical analyses were determined using specific kits, according to the manufacturer’s instructions. Results The RUN group showed a significant increase in plasma BDNF levels (P = 0.007) and H4 hypoacetylation status (P < 0.001) in peripheral mononuclear cells (PBMCs), compared with the SED individuals. The RUN group also presented significantly lower values in TUG, an indicative of better motor performance (P = 0.02). Conclusions Collectively, the current study data suggested that the modulation of histone H4 acetylation status might emerge as an important biomarker related to the elderly runners phenotype. The data also supported the idea that the running practice enhances peripheral BDNF levels, which could be linked to the functional mobility improvement in the elderly runners. |
| Databáze: | OpenAIRE |
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