Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas
| Autor: | Weiguo Lu, Xiaoyun Wan, Liya Dong, Yizhen Niu, Xiaofei Zhang, Lina Yu, Feng Zhou, Lili Chen, Amanda L. Strickland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty CA-19-9 Antigen Uterine Cervical Neoplasms Adenocarcinoma Gastroenterology HPV-independent endocervical adenocarcinoma (HPVI ECA) Stromal Invasion Surgical oncology Risk Factors Internal medicine Serum CA19–9 Genetics Medicine Humans In patient Stage (cooking) Pathological RC254-282 Aged Neoplasm Staging Retrospective Studies business.industry Research Papillomavirus Infections Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged Gastric type Prognosis Gastric-type Progression-Free Survival Endocervical Adenocarcinoma Vaginal Discharge Oncology Clinicopathological features Female business |
| Zdroj: | BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021) BMC Cancer |
| ISSN: | 1471-2407 |
| Popis: | Background We aimed to analyze the clinicopathological features and outcomes of patients with gastric-type of HPV-independent endocervical adenocarcinoma (GAS HPVI ECA), and compare them with non-GAS HPVI ECA cases. Methods Thirty-eight GASs [including 17 minimal deviation adenocarcinoma (MDA), 21 non-MDA GAS] and 17 non-GAS HPVI ECAs were studied. Data of clinical features, pathological characteristics, treatment, and outcomes were evaluated. Results The median age of patients with GAS and non-GAS HPVI ECA was 46 and 48 years, respectively (p = 0.93). Compared with non-GAS HPVI ECAs, GAS had more common complains of vaginal watery discharge (p = 0.04). GAS cases were also associated with higher clinical stage (p = 0.036), more common in deeper cervical stromal invasion (p = 0.002) and lymphoavascular invasion (p = 0.044). GAS was associated with worse median progression-free survival (PFS) (p = 0.02) and median overall survival (OS) (p = 0.03) over patients with non-GAS HPVI ECAs. MDA had similar clinical and pathological features and prognosis compared with non-MDA GAS. Of note, serum CA19–9 levels were significantly higher in GAS than that in non-GAS HPVI ECA cases. Conclusions GAS cases were more likely to have high risk pathological factors and poorer PFS and OS compared with non-GAS HPVI ECAs. Serum CA19–9 may be helpful for diagnosis and screening in patients with GAS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|