Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats
Autor: | Ali Akbar Rashidi, Mostafa Ghardashi, Ali Akbar Taherian, Mohammad Sajad Sajadian, Zarichehr Vakili, Mohsen Taghizadeh |
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Rok vydání: | 2016 |
Předmět: |
Blood Glucose
Male 0301 basic medicine Rosaceae Rosa 01 natural sciences Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound Oral administration Diabetes mellitus Botany medicine Animals Hypoglycemic Agents Rats Wistar Medicinal plants Pancreas Hypolipidemic Agents geography geography.geographical_feature_category Ethanol Traditional medicine biology Plant Extracts Rosa canina Islet biology.organism_classification medicine.disease Streptozotocin Lipids Rats 0104 chemical sciences 010404 medicinal & biomolecular chemistry 030104 developmental biology chemistry Fruit medicine.drug |
Zdroj: | Journal of Evidence-Based Complementary & Alternative Medicine. 21:NP25-NP30 |
ISSN: | 2156-5899 2156-5872 |
DOI: | 10.1177/2156587215612626 |
Popis: | Rosa canina L. (Rosaceae) has been traditionally used as a medicinal plant. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of Rosa canina fruit extract in streptozotocin induced diabetic rats. The results showed oral administration of Rosa canina fruit extract significantly ameliorated the high levels of blood glucose compared with the control group. Serum triglyceride levels significantly decreased by the administration of Rosa canina extract compared with control. Histopathological examinations showed that the Rosa canina extract improved islets necrotic and regenerated pancreatic islet cells. Rosa canina extract has the antihyperglycemic and antihyperlipidemic effects in streptozotocin-induced diabetic rats. |
Databáze: | OpenAIRE |
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