Genetic determinism of bone and mineral metabolism in meat-type chickens: A QTL mapping study

Autor: Nadine Sellier, Marie-Yvonne Boscher, Sandrine Mignon-Grasteau, Céline Chantry-Darmon, Agnès Narcy, Marie Chabault-Dhuit, Elisabeth Le Bihan-Duval
Přispěvatelé: Unité de Recherches Avicoles (URA), Institut National de la Recherche Agronomique (INRA), Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA), Pôle d'Expérimentation Avicole de Tours (UE PEAT), ANR CHIEF
Rok vydání: 2016
Předmět:
0301 basic medicine
Candidate gene
cartographie de qtl
lcsh:Diseases of the musculoskeletal system
QTL
Endocrinology
Diabetes and Metabolism
[SDV]Life Sciences [q-bio]
poulet
TDM
tibia dry matter weight
Quantitative trait locus
Biology
Environment
BBS
bone breaking strength
Article
TL
tibia length
Genetic determinism
03 medical and health sciences
Animal science
TV
tibia volume
Chromosome 18
formation des os
Orthopedics and Sports Medicine
[INFO]Computer Science [cs]
Tibia
Allele
Bone
ComputingMilieux_MISCELLANEOUS
Genetics
métabolisme minéral
BW
body weight
0402 animal and dairy science
Chromosome
TA
tibia ash weight
Phosphorus
04 agricultural and veterinary sciences
TD
tibia diameter
Heritability
Genetic parameters
musculoskeletal system
RETP
percentage of retained phosphorus
040201 dairy & animal science
Chicken
phosphore
PP
phosphorus concentration in plasma
030104 developmental biology
lcsh:RC925-935
Zdroj: Bone Reports
Bone Reports, 2016, 5, pp.43-50. ⟨10.1016/j.bonr.2016.02.004⟩
Bone Reports, Vol 5, Iss, Pp 43-50 (2016)
Bone Reports (5), 43-50. (2016)
ISSN: 2352-1872
DOI: 10.1016/j.bonr.2016.02.004
Popis: Skeletal integrity in meat-type chickens is affected by many factors including rapid growth rate, nutrition and genetics. To investigate the genetic basis of bone and mineral metabolism, a QTL detection study was conducted in an intercross between two lines of meat-type chickens divergently selected for their high (D +) or low (D −) digestive efficiency. Tibia size (length, diameter, volume) and ash content were determined at 3 weeks of age as well as phosphorus (P) retention and plasma concentration. Heritability of these traits and their genetic correlations with digestive efficiency were estimated. A QTL mapping study was performed using 3379 SNP markers. Tibia size, weight, ash content and breaking strength were highly heritable (0.42 to 0.61). Relative tibia diameter and volume as well as P retention were strongly and positively genetically correlated with digestive efficiency (0.57 to 0.80). A total of 35 QTL were identified (9 for tibia weight, 13 for tibia size, 5 for bone strength, 5 for bone mineralization, 2 for plasma P concentration and 1 for P retention). Six QTL were genome-wide significant, and 3 QTL for tibia relative volume, weight and ash weight on chromosome 6 were fixed, the positive allele coming from the D-line. For two QTL for ash content on chromosome 18 and relative tibia length on chromosome 26, the confidence intervals were small enough to identify potential candidate genes. These findings support the evidence of multiple genetic loci controlling bone and mineral metabolism. The identification of candidate genes may provide new perspectives in the understanding of bone regulation, even beyond avian species.
Highlight • The genetic basis of bone and mineral metabolism is investigated in a QTL detection study in meat-type chickens. • Thirty-five QTL were identified for tibia weight, size, strength and mineralization, plasma P concentration and P retention. • Six QTL were genome-wide significant. • Three QTL for tibia relative volume, weight and ash weight on chromosome 6 were fixed. • These findings support the evidence of multiple genetic loci controlling bone and mineral metabolism.
Databáze: OpenAIRE
Externí odkaz: