Distinct resting-state brain activity in patients with functional constipation
| Autor: | Yuanyuan Wang, Qianqian Meng, Yongzhan Nie, Huaning Wang, Guangbin Cui, Jie Tian, Weiwei Cai, Jianyong Zheng, Karen M. von Deneen, Qiaoyun Liu, Yi Zhang, Qiang Zhu, Yu Han, Guanya Li, Shijun Duan, Jizheng Zhao |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Sensory processing Gastrointestinal Diseases Brain activity and meditation Rest medicine.medical_treatment Sensory system Brain mapping Young Adult 03 medical and health sciences 0302 clinical medicine Neuroimaging Image Processing Computer-Assisted medicine Humans Brain Mapping Resting state fMRI General Neuroscience Brain Motor control Middle Aged medicine.disease Magnetic Resonance Imaging Functional constipation Female 030211 gastroenterology & hepatology Psychology Constipation Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 632:141-146 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2016.08.042 |
| Popis: | Functional constipation (FC) is a common functional gastrointestinal disorder (FGID) with a higher prevalence in clinical practice. The primary brain regions involved in emotional arousal regulation, somatic, sensory and motor control processing have been identified with neuroimaging in FGID. It remains unclear how these factors interact to influence the baseline brain activity of patients with FC. In the current study, we combined resting-state fMRI (RS-fMRI) with Granger causality analysis (GCA) to investigate the causal interactions of the brain areas in 14 patients with FC and in 26 healthy controls (HC). Our data showed significant differences in baseline brain activities in a number of major brain regions implicated in emotional process modulation (i.e. dorsal anterior cingulate cortex-dACC, anterior insula-aINS, orbitofrontal cortex-OFC, hippocampus-HIPP), somatic and sensory processing, and motor control (i.e., supplementary motor area-SMA, precentral gyrus-PreCen) (P |
| Databáze: | OpenAIRE |
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