The diurnal variation of serum hyaluronan in health and disease
| Autor: | R. Pettersson, Ulla B.G. Laurent, U. Björklund, Ulla Lindqvist, A. Nyberg, A. Tengblad, Helena Eriksson, Anna Engström-Laurent |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
medicine.medical_specialty Eye Diseases Clinical Biochemistry Significant elevation Skin Diseases Arthritis Rheumatoid chemistry.chemical_compound Primary biliary cirrhosis Internal medicine Healthy volunteers Hyaluronic acid medicine Humans Hyaluronic Acid Morning Aged business.industry Liver Cirrhosis Biliary Diurnal temperature variation General Medicine Serum concentration Middle Aged medicine.disease Circadian Rhythm Endocrinology chemistry Rheumatoid arthritis business |
| Zdroj: | Scandinavian journal of clinical and laboratory investigation. 48(8) |
| ISSN: | 0036-5513 |
| Popis: | The variation of the serum concentration of hyaluronan during the day and between days has been investigated. In a group of healthy volunteers, the mean hyaluronan level was very stable over time except for a moderate but significant elevation after rising from bed in the morning. Patients with rheumatoid arthritis showed markedly increased hyaluronan concentrations 0.5-2 h after leaving bed. Patients with primary biliary cirrhosis exhibited high and rather constant levels during the day. A reference group of hospitalized patients with other diseases did not show any diurnal variation. The best reproducibility in hyaluronan determinations is obtained if specimens are taken before the subjects rise from bed or a few hours later, i.e. after the morning elevation of serum hyaluronan has subsided. In rheumatoid arthritis valuable information can be obtained by repeated sampling during the morning hours. |
| Databáze: | OpenAIRE |
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