Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
| Autor: | Fábio P.L. Silva, Claudio G. L. Junior, Natália G. de Andrade, Mário L. A. A. Vasconcellos, Ramon G. de Oliveira, Fernanda Lima Subrinho |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Antiparasitic
medicine.drug_class temperature effect General Chemistry microwave-promoted reactions Adduct chemistry.chemical_compound antiparasitic compounds chemistry Morita-Baylis-Hillman reaction Polymer chemistry Microwave irradiation medicine Organic chemistry Acrylonitrile Methyl acrylate thermodynamic control |
| Zdroj: | Journal of the Brazilian Chemical Society, Volume: 22, Issue: 11, Pages: 2220-2224, Published: NOV 2011 Journal of the Brazilian Chemical Society v.22 n.11 2011 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| ISSN: | 0103-5053 |
| DOI: | 10.1590/s0103-50532011001100028 |
| Popis: | It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 ºC or conventional protocol at 0 ºC to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 ºC. Relatamos a síntese de 24 adutos de Morita-Baylis-Hillman (3a-3l/6a-6l) usando irradiação de microondas a 80 ºC ou protocolo convencional a 0 ºC para promover reações entre aldeídos aromáticos e acrilato de metila ou acrilonitrila (81-99%). Provamos que a reação de formação do acrilato de 2-hidroxi(4-bromofenil)metila é reversível a 120 ºC. |
| Databáze: | OpenAIRE |
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