Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils
| Autor: | Franziska Jundt, Anagnostopoulos, I., Bommert, K., Emmerich, F., Muller, G., Foss, Hd, Royer, Hd, Stein, H., Dorken, B. |
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| Rok vydání: | 1999 |
| Předmět: |
Chemokine CCL11
Transcription Genetic Chemotactic Factors Eosinophil Immunology Enzyme-Linked Immunosorbent Assay Biochemistry Th2 Cells immune system diseases hemic and lymphatic diseases Tumor Cells Cultured Humans RNA Messenger Reed-Sternberg Cells Cells Cultured In Situ Hybridization Skin Cell Biology Hematology respiratory system Fibroblasts Hodgkin Disease Chemotaxis Leukocyte Gene Expression Regulation Chemokines CC Cytokines Lymph Nodes HeLa Cells |
| Zdroj: | ResearcherID |
| ISSN: | 0006-4971 |
| Popis: | Hodgkin’s disease is histopathologically characterized by the relative scarcity of neoplastic Hodgkin and Reed-Sternberg cells and for yet unknown reasons by an abundant reactive background of T lymphocytes and often eosinophils. Eotaxin is a CC-chemokine attracting eosinophils and T helper 2 (Th2) cells in allergic inflammation. We now report that eotaxin is strongly expressed in fibroblasts of Hodgkin’s disease tissues, whereas Hodgkin/Reed-Sternberg cells do not express this chemokine. In tissue culture, Hodgkin’s disease tumor cells induce eotaxin expression in cocultured dermal fibroblasts in a concentration leading to a specific chemotactic response of a Th2 cell clone. Production of tumor necrosis factor- (TNF-) by Hodgkin/Reed-Sternberg cells appears to be responsible for this induction, because blocking of TNF- by neutralizing antibodies prevented fibroblast eotaxin expression. Our data suggest that eotaxin is involved in the pathobiology of Hodgkin’s disease by contributing to eosinophil and T-lymphocyte recruitment. |
| Databáze: | OpenAIRE |
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