Local applications but global implications: Can pesticides drive microorganisms to develop antimicrobial resistance?
| Autor: | N. Sethunathan, Kadiyala Venkateswarlu, Balasubramanian Ramakrishnan, Mallavarapu Megharaj |
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| Rok vydání: | 2019 |
| Předmět: |
Environmental Engineering
010504 meteorology & atmospheric sciences Microorganism 010501 environmental sciences Biology 01 natural sciences Antibiotic resistance Environmental Chemistry Microbiome Pesticides Waste Management and Disposal Biotransformation 0105 earth and related environmental sciences Resistance (ecology) business.industry Chemotaxis Microbiota Drug Resistance Microbial Pesticide Antimicrobial Pollution Biotechnology Environmental Pollutants Efflux Adaptation business |
| Zdroj: | Science of The Total Environment. 654:177-189 |
| ISSN: | 0048-9697 |
| DOI: | 10.1016/j.scitotenv.2018.11.041 |
| Popis: | Pesticides are an important agricultural input, and the introduction of new active ingredients with increased efficiencies drives their higher production and consumption worldwide. Inappropriate application and storage of these chemicals often contaminate plant tissues, air, water, or soil environments. The presence of pesticides can lead to developing tolerance, resistance or persistence and even the capabilities to degrade them by the microbiomes of theses environments. The pesticide-degrading microorganisms gain and employ several mechanisms for attraction (chemotaxis), membrane transport systems, efflux pumps, enzymes and genetical make-up with plasmid and chromosome encoded catabolic genes for degradation. Even the evolution and the mechanisms of inheritance for pesticide-degradation as a functional trait in several microorganisms are beginning to be understood. Because of the commonalities in the microbial responses of sensing and uptake, and adaptation due to the selection pressures of pesticides and antimicrobial substances including antibiotics, the pesticide-degraders have higher chances of possessing antimicrobial resistance as a surplus functional trait. This review critically examines the probabilities of pesticide contamination of soil and foliage, the knowledge gaps in the regulation and storage of pesticide chemicals, and the human implications of pesticide-degrading microorganisms with antimicrobial resistance in the global strategy of 'One Health'. |
| Databáze: | OpenAIRE |
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