Adrenocorticotropic hormone, β-endorphin and cortisol responses to oCRH in Unipolar Depressed Patients Pretreated with Dexamethasone
| Autor: | Joseph R. Calabrese, P. Blockx, Paul Cosyns, Herbert Y. Meltzer, Peter D'Hondt, Michael Maes |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Cortisol secretion endocrine system medicine.medical_specialty Hydrocortisone Corticotropin-Releasing Hormone Adrenocorticotropic hormone Severity of Illness Index Dexamethasone Adrenocorticotropic Hormone Internal medicine medicine Humans Beta (finance) Biological Psychiatry Pharmacology Depressive Disorder business.industry beta-Endorphin Middle Aged Hospitalization Endocrinology Dexamethasone suppression test Corticotropic cell business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug Hormone |
| Zdroj: | Progress in neuro-psychopharmacology and biological psychiatry |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/0278-5846(94)90093-0 |
| Popis: | 1. Corticotropin-releasing hormone (ovine CRH, 100 micrograms intravenous bolus) was given to 63 unipolar depressed inpatients following the 1 mg overnight dexamethasone suppression test (DST). The depressed patients included 18 minor, 24 simple major and 21 melancholic subtypes. 2. Baseline or postdexamethasone plasma levels of intact adrenocorticotropic hormone (ACTH), beta-endorphin/beta-lipotropin (beta END/beta LPH), cortisol, and dexamethasone were measured, as well as the post DST+CRH hormone responses. 3. CRH administration 9.5 hr after dexamethasone resulted in a significant enhancement of ACTH, beta END/beta LPH and cortisol secretion. The post DST+CRH ACTH and beta END/beta LPH- but not cortisol-values exceeded their baseline hormone levels. The post DST+CRH ACTH--but not beta END/beta LPH or cortisol-levels were significantly higher in major depressives compared to minor depressives. The post DST+CRH ACTH and beta END/beta LPH--but not cortisol-levels were significantly higher in DST nonsuppressors than suppressors. The post DST+CRH ACTH levels were significantly and positively related to severity of illness. 4. The results provide evidence that the pathophysiology underlying the abnormal DST+CRH and DST tests in melancholia is localized at the pituitary level and may consist of a CRH-driven breakthrough of corticotropic cell secretion synergized by central and peripheral agents, in conjunction with a decrease in glucocorticoid feedback suppressibility. |
| Databáze: | OpenAIRE |
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