Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain
| Autor: | R.B. Vartanyan, P.A. Patriarca, Obrosova-Serova Np, S.G. Cheshik, Alan P. Kendal, V.M. Zhdanov, B.V. Yagodovskii, G.I. Alexandrova, Maurice W. Harmon, L.N. Kupryashina, F.I. Polezhaev, N.I. Lonskaya, A.N. Slepushkin |
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| Rok vydání: | 1988 |
| Předmět: |
Influenza vaccine
Orthomyxoviridae medicine.disease_cause Antibodies Viral Immunoglobulin G Influenza A Virus H1N1 Subtype Antibody Specificity Influenza A virus medicine Humans Child Infectivity Recombination Genetic Attenuated vaccine General Veterinary General Immunology and Microbiology biology business.industry Vaccination Public Health Environmental and Occupational Health Hemagglutination Inhibition Tests biology.organism_classification Virology Immunoglobulin A Infectious Diseases Influenza Vaccines Immunology biology.protein Molecular Medicine Antibody business |
| Zdroj: | Vaccine. 6(1) |
| ISSN: | 0264-410X |
| Popis: | Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay. |
| Databáze: | OpenAIRE |
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