Understanding COPD-overlap syndromes
| Autor: | Pei Yee Tiew, Mariko Siyue Koh, Anthony Yii, Sanjay H. Chotirmall, Adrian Chan, Valerie Fei Lee Yong, Tuang Yeow Poh, Micheál Mac Aogáin |
|---|---|
| Přispěvatelé: | Lee Kong Chian School of Medicine (LKCMedicine) |
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pathology urologic and male genital diseases Overlap syndrome Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine medicine Humans Immunology and Allergy 030212 general & internal medicine Respiratory system Asthma COPD Bronchiectasis business.industry Chronic obstructive pulmonary disease fungi Public Health Environmental and Occupational Health food and beverages Syndrome medicine.disease Obstructive sleep apnea 030228 respiratory system Lung disease business |
| Zdroj: | Expert Review of Respiratory Medicine. 11:285-298 |
| ISSN: | 1747-6356 1747-6348 |
| DOI: | 10.1080/17476348.2017.1305895 |
| Popis: | Introduction: Chronic obstructive pulmonary disease accounts for a large burden of lung disease. It can 'overlap' with other respiratory diseases including bronchiectasis, fibrosis and obstructive sleep apnea (OSA). While COPD alone confers morbidity and mortality, common features with contrasting clinical outcomes can occur in COPD 'overlap syndromes'. Areas covered: Given the large degree of heterogeneity in COPD, individual variation to treatment is adopted based on its observed phenotype, which in turn overlaps with features of other respiratory disease states such as asthma. This is coined asthma-COPD overlap syndrome ('ACOS'). Other examples of such overlapping clinical states include bronchiectasis-COPD ('BCOS'), fibrosis-COPD ('FCOS') and OSA-COPD ('OCOS'). The objective of this review is to highlight similarities and differences between the COPD-overlap syndromes in terms of risk factors, pathophysiology, diagnosis and potential treatment differences. Expert commentary: As a consequence of COPD overlap syndromes, a transition from the traditional 'one size fits all' treatment approach is necessary. Greater treatment stratification according to clinical phenotype using a precision medicine approach is now required. In this light, it is important to recognize and differentiate COPD overlap syndromes as distinct disease states compared to individual diseases such as asthma, COPD, fibrosis or bronchiectasis. Accepted version |
| Databáze: | OpenAIRE |
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