Multi-antigen vaccines based on complex adenovirus vectors induce protective immune responses against H5N1 avian influenza viruses
| Autor: | John Y. Dong, David H. Holman, Danher Wang, Nicholas U. Raja, Nutan Mytle, Min Luo, Kevin M. Moore, Jan Woraratanadharm |
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| Rok vydání: | 2008 |
| Předmět: |
Male
T-Lymphocytes Genetic Vectors Biology Antibodies Viral medicine.disease_cause H5N1 genetic structure Virus Adenoviridae Mice Immune system Orthomyxoviridae Infections Antigen Pandemic medicine Animals Antigens Viral Influenza A Virus H5N1 Subtype General Veterinary General Immunology and Microbiology Transmission (medicine) Body Weight Public Health Environmental and Occupational Health Pandemic influenza virus diseases Survival Analysis Virology Influenza A virus subtype H5N1 Infectious Diseases Influenza Vaccines Immunology Molecular Medicine |
| Zdroj: | Vaccine. 26:2627-2639 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2008.02.053 |
| Popis: | There are legitimate concerns that the highly pathogenic H5N1 avian influenza virus could adapt for human-to-human transmission and cause a pandemic similar to the 1918 "Spanish flu" that killed 50 million people worldwide. We have developed pandemic influenza vaccines by incorporating multiple antigens from both avian and Spanish influenza viruses into complex recombinant adenovirus vectors. In vaccinated mice, these vaccines induced strong humoral and cellular immune responses against pandemic influenza virus antigens, and protected vaccinated mice against lethal H5N1 virus challenge. These results indicate that this multi-antigen, broadly protective vaccine may serve as a safer and more effective approach than traditional methods for development of a pandemic influenza vaccine. |
| Databáze: | OpenAIRE |
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