Wound Healing and Anti-Inflammatory Effect in Animal Models ofCalendula officinalisL. Growing in Brazil
| Autor: | Neusa Margarida Paulo, Marina Clare Vinaud, Ruy de Souza Lino Junior, Leonice M.F. Tresvenzol, Leila Maria Leal Parente, José Realino de Paula |
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| Rok vydání: | 2012 |
| Předmět: |
food.ingredient
Article Subject biology Traditional medicine business.industry medicine.drug_class Rat model lcsh:Other systems of medicine lcsh:RZ201-999 biology.organism_classification Anti-inflammatory Chorioallantoic membrane food Complementary and alternative medicine Calendula officinalis Herb Officinalis Medicine business Wound healing Antibacterial activity Research Article |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 1741-427X |
| Popis: | Calendula officinalisis an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis. The antibacterial activity of the extract and fractions was also evaluated. This experimental study revealed thatC. officinalispresented anti-inflammatory and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and proliferative phases of the healing process. |
| Databáze: | OpenAIRE |
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