Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

Autor: Calvin Pan, Elisa Deriu, Sammy David Benavidez, Xuesong He, Genhong Cheng, Gayle M. Boxx, Nora Rozengurt, Wenyuan Shi, Lujia Cen
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Bacterial Diseases
Viral Diseases
Salmonellosis
Salmonella infection
Pathology and Laboratory Medicine
Mice
Salmonella
Medicine and Health Sciences
lcsh:QH301-705.5
Mice
Knockout
Gastrointestinal tract
Coinfection
Animal Models
Genomics
Antimicrobial
3. Good health
Bacterial Pathogens
Infectious Diseases
Medical Microbiology
Enterobacter Infections
Salmonella Typhimurium
Interferon Type I
Anaerobic bacteria
Pathogens
Anatomy
Research Article
lcsh:Immunologic diseases. Allergy
030106 microbiology
Immunology
Immunoblotting
Mouse Models
Enzyme-Linked Immunosorbent Assay
Microbial Genomics
Biology
Research and Analysis Methods
Real-Time Polymerase Chain Reaction
Microbiology
Virus
03 medical and health sciences
Immune system
Model Organisms
Enterobacteriaceae
Orthomyxoviridae Infections
Virology
medicine
Genetics
Animals
Microbiome
Colitis
Molecular Biology
Microbial Pathogens
Salmonella Infections
Animal
Bacteria
Organisms
Biology and Life Sciences
medicine.disease
Influenza
Gastrointestinal Microbiome
Gastrointestinal Tract
Mice
Inbred C57BL
Disease Models
Animal
030104 developmental biology
lcsh:Biology (General)
Parasitology
lcsh:RC581-607
Digestive System
Zdroj: PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 5, p e1005572 (2016)
ISSN: 1553-7374
1553-7366
Popis: Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also develop gastrointestinal symptoms, such as vomiting and diarrhea. However, the molecular mechanisms remain incompletely defined. Using an influenza mouse model, we found that influenza pulmonary infection can significantly alter the intestinal microbiota profile through a mechanism dependent on type I interferons (IFN-Is). Notably, influenza-induced IFN-Is produced in the lungs promote the depletion of obligate anaerobic bacteria and the enrichment of Proteobacteria in the gut, leading to a “dysbiotic” microenvironment. Additionally, we provide evidence that IFN-Is induced in the lungs during influenza pulmonary infection inhibit the antimicrobial and inflammatory responses in the gut during Salmonella-induced colitis, further enhancing Salmonella intestinal colonization and systemic dissemination. Thus, our studies demonstrate a systemic role for IFN-Is in regulating the host immune response in the gut during Salmonella-induced colitis and in altering the intestinal microbial balance after influenza infection.
Author Summary Influenza is a respiratory illness. Symptoms of flu include fever, headache, extreme tiredness, dry cough, sore throat, runny or stuffy nose, and muscle aches. Some people, especially children, can have additional gastrointestinal symptoms, such as nausea, vomiting, and diarrhea. In humans, there is no evidence that the influenza virus replicates in the intestine. Using an influenza mouse model, we found that influenza infection alters the intestinal microbial community through a mechanism dependent on type I interferons induced in the pulmonary tract. Futhermore, we demonstrate that influenza-induced type I interferons increase the host susceptibility to Salmonella intestinal colonization and dissemination during secondary Salmonella-induced colitis through suppression of host intestinal immunity.
Databáze: OpenAIRE
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