Photo- and pH-Tunable Multicolor Fluorescent Nanoparticle-Based Spiropyran- and BODIPY-Conjugated Polymer with Graphene Oxide
| Autor: | Jung Eun Lee, Haeshin Lee, Shazid Md. Sharker, Ji Hoon Jeong, Sung Young Park, Insik In, Sung Min Kim, Chan Jin Jeong |
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| Rok vydání: | 2014 |
| Předmět: |
Boron Compounds
Indoles Polymers Color Nanoparticle Nanotechnology Conjugated system Microscopy Atomic Force Photochemistry Biochemistry law.invention Nanomaterials chemistry.chemical_compound law Benzopyrans Fluorescent Dyes Spiropyran Microscopy Confocal Quenching (fluorescence) Graphene Organic Chemistry Oxides General Chemistry Hydrogen-Ion Concentration Nitro Compounds Fluorescence Spectrometry Fluorescence chemistry Nanoparticles Graphite BODIPY |
| Zdroj: | Chemistry - An Asian Journal. 9:2921-2927 |
| ISSN: | 1861-4728 |
| DOI: | 10.1002/asia.201402399 |
| Popis: | We report a stimuli-responsive fluorescent nanomaterial, based on graphene oxide coupled with a polymer conjugated with photochromic spiropyran (SP) dye and hydrophobic boron dipyrromethane (BODIPY) dye, for application in triggered target multicolor bioimaging. Graphene oxide (GO) was reduced by catechol-conjugated polymers under mildly alkaline conditions, which enabled to formation of functionalized multicolor graphene nanoparticles that can be induced by irradiation with UV light and by changing the pH from acidic to neutral. Investigation of these nanoparticles by using AFM, fluorescence emission, and in vitro cell and in vivo imaging revealed that they show different tunable colors in bioimaging applications and, more specifically, in cancer-cell detection. The stability, biocompatibility, and quenching efficacy of this nanocomposite open a different perspective for cell imaging in different independent colors, sequentially and simultaneously. |
| Databáze: | OpenAIRE |
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