Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system

Autor: Jeffrey B. Tatro, Richard B. Simerly, Kathleen G. Mountjoy, Linda Roselli-Rehfuss, Linda S. Robbins, Roger D. Cone, Margaret L. Entwistle, Marty Mortrud, Malcolm J. Low
Rok vydání: 1993
Předmět:
Male
endocrine system
medicine.medical_specialty
Pro-Opiomelanocortin
Recombinant Fusion Proteins
Molecular Sequence Data
Hypothalamus
Biology
Polymerase Chain Reaction
Rats
Sprague-Dawley
Prosencephalon
Adrenocorticotropic Hormone
Proopiomelanocortin
Melanocortin receptor
Arcuate nucleus
Internal medicine
Limbic System
medicine
Animals
Humans
ACTH receptor
Amino Acid Sequence
Melanocyte-Stimulating Hormones
RNA
Messenger
Receptors
Pituitary Hormone
Cloning
Molecular
In Situ Hybridization
Melanocortins
Multidisciplinary
Sequence Homology
Amino Acid
integumentary system
Receptors
Melanocortin
digestive
oral
and skin physiology
Brain
Blotting
Northern
Melanocortin 3 receptor
Rats
Kinetics
Endocrinology
nervous system
Organ Specificity
biology.protein
Melanocortin
hormones
hormone substitutes
and hormone antagonists
Research Article
Adenylyl Cyclases
Receptor
Melanocortin
Type 3
Zdroj: Proceedings of the National Academy of Sciences. 90:8856-8860
ISSN: 1091-6490
0027-8424
DOI: 10.1073/pnas.90.19.8856
Popis: Corticotropin (ACTH) and melanotropin (MSH) peptides (melanocortins) are produced not only in the pituitary but also in the brain, with highest concentrations in the arcuate nucleus of the hypothalamus and the commisural nucleus of the solitary tract. We have identified a receptor for MSH and ACTH peptides that is specifically expressed in regions of the hypothalamus and limbic system. This melanocortin receptor (MC3-R) is found in neurons of the arcuate nucleus known to express proopiomelanocortin (POMC) and in a subset of the nuclei to which these neurons send projections. The MC3-R is 43% identical to the MSH receptor present in melanocytes and is strongly coupled to adenylyl cyclase. Unlike the MSH or ACTH receptors, MC3-R is potently activated by gamma-MSH peptides, POMC products that were named for their amino acid homology with alpha- and beta-MSH, but lack melanotropic activity. The primary biological role of the gamma-MSH peptides is not yet understood. The location and properties of this receptor provide a pharmacological basis for the action of POMC peptides produced in the brain and possibly a specific physiological role for gamma-MSH.
Databáze: OpenAIRE
Externí odkaz: