Relationship between inducible NOS single-nucleotide polymorphisms and hypertension in Han Chinese
| Autor: | Zhenhua Wang, Z. Zhai, Dan Wang, S. Chen, Hong-qiang Ren, Li Wang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty China Nitric Oxide Synthase Type II Single-nucleotide polymorphism 030204 cardiovascular system & hematology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Internal medicine Genotype Genetic model medicine Humans Genetic Predisposition to Disease Allele frequency Aged Genetics business.industry Nucleotides Confounding Case-control study Odds ratio Middle Aged 030104 developmental biology Endocrinology Case-Control Studies Hypertension Female Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Herz. 43(5) |
| ISSN: | 1615-6692 |
| Popis: | Inducible nitric oxide synthase (iNOS) single-nucleotide polymorphisms have been reported to confer susceptibility to hypertension, but no consensus has been reached. The aim of this study was to investigate the association between iNOS and hypertension in a Chinese population. This was a case-control study including 1172 hypertensive and 1172 control subjects to investigate the association between iNOS and hypertension. There were significant differences in the distribution of genotype and allele frequencies of rs2779249 and rs2297518 between hypertensive and normotensive subjects. Logistic regression analyses were performed with different genetic models (additive, dominant, recessive) adjusting for confounding risk covariates, including age, sex, body mass index, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, smoking, drinking, and family history of hypertension. The odds ratio (OR) was 1.27 (1.12, 1.44) in the additive model, 1.31 (1.09, 1.59) in the dominant, and 1.68 (1.28, 2.19) in the recessive model of rs2779249; the OR was 1.26 (1.06, 1.50) in the additive model and 1.46 (1.13, 1.89) in the dominant model of rs2297518. The current study provides evidence that iNOS is strongly associated with hypertension. |
| Databáze: | OpenAIRE |
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