Poliovirus excretion among persons with primary immune deficiency disorders: summary of a seven-country study series
| Autor: | Nadia Driss, Li Li, Roland W. Sutter, Ondrej Mach, Rajiva da Silva, Olga Ivanova, Marysia Tiongco-Recto, Hossain M.S. Sazzad, Anna-Lea Kahn, Shohreh Shahmahmoodi |
|---|---|
| Přispěvatelé: | Chinese Center for Disease Control and Prevention, Chumakov Institute of Poliomyelitis and Viral Encephalitides of Russian Academy of Medical Sciences, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), University of the Philippines Cebu (UP Cebu), Medical research Institute, Tehran University of Medical Sciences (TUMS), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), World Health Organisation (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The World Health Organization, Centers for Disease Control and Prevention, For Iran: Ministry of Health and Medical Education |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics viruses [SDV]Life Sciences [q-bio] OPV MESH: Africa medicine.disease_cause primary immune deficiency Russia MESH: Virus Shedding 0302 clinical medicine Informed consent MESH: Child Pelvic inflammatory disease Paralysis MESH: Immunocompromised Host Immunology and Allergy 030212 general & internal medicine Child 0303 health sciences MESH: Russia MESH: Asia Poliovirus MESH: Infant 3. Good health Virus Shedding Infectious Diseases MESH: Young Adult Child Preschool [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Female medicine.symptom MESH: Poliovirus Adult medicine.medical_specialty Asia MESH: Immunologic Deficiency Syndromes Adolescent Developing country vaccine-derived polioviruses Excretion 03 medical and health sciences Immunocompromised Host Young Adult Immune system medicine Humans poliovirus excretion 030304 developmental biology MESH: Adolescent MESH: Humans business.industry MESH: Child Preschool Immunologic Deficiency Syndromes Infant MESH: Adult MESH: Male Country study Immunology Africa MESH: Poliomyelitis business MESH: Female Poliomyelitis |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2014, 210 (suppl 1), pp.S368-72. ⟨10.1093/infdis/jiu065⟩ |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiu065⟩ |
| Popis: | Background Persons with primary immune deficiency disorders (PID), especially those disorders affecting the B-cell system, are at substantially increased risk of paralytic poliomyelitis and can excrete poliovirus chronically. However, the risk of prolonged or chronic excretion is not well characterized in developing countries. We present a summary of a country study series on poliovirus excretion among PID cases. Methods Cases with PID from participating institutions were enrolled during the first year and after obtaining informed consent were tested for polioviruses in stool samples. Those cases excreting poliovirus were followed on a monthly basis during the second year until 2 negative stool samples were obtained. Results A total of 562 cases were enrolled in Bangladesh, China, Iran, Philippines, Russia, Sri Lanka, and Tunisia during 2008-2013. Of these, 17 (3%) shed poliovirus, including 2 cases with immunodeficient vaccine-derived poliovirus. Poliovirus was detected in a single sample from 5/17 (29%) cases. One case excreted for more than 6 months. None of the cases developed paralysis during the study period. Conclusions Chronic polioviruses excretion remains a rare event even among individuals with PID. Nevertheless, because these individuals were not paralyzed they would have been missed by current surveillance; therefore, surveillance for polioviruses among PID should be established. |
| Databáze: | OpenAIRE |
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