Experience and Reason: Twenty-Year Follow-Up of Protective Immunity of the Oka Strain Live Varicella Vaccine
| Autor: | Takehiko Yazaki, Tetsushi Yoshikawa, Motohiro Shibata, Ikuko Kobayashi, Sadao Suga, Yoshizo Asano, Shigemitsu Ito, Kazuo Tsuzuki |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Herpesvirus 3 Human Pediatrics medicine.medical_specialty Adolescent Varicella vaccine Antibodies Viral Vaccines Attenuated Chickenpox Vaccine Chickenpox Immunity medicine Humans Child Licensure Immunity Cellular business.industry Immunogenicity Infant Viral Vaccines Vaccination Clinical trial Child Preschool Antibody Formation Pediatrics Perinatology and Child Health Immunology Female Viral disease business Follow-Up Studies |
| Zdroj: | Pediatrics. 94:524-526 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.94.4.524 |
| Popis: | Since the first report on the development of a live attenuated varicella vaccine in 1974, the vaccine has been studied extensively, with largely favorable results, in both healthy and leukemic children. It is now licensed in Japan, Korea, and some European countries, and is being considered for licensure in the United States. Although various clinical trials have established the safety, immunogenicity, and the efficacy of the vaccine, concern has been expressed that waning immunity in the vaccine recipients might allow the occurrence of more severe varicella later in life. We show data relevant to this concern on the approximately 20-year follow-up study of the vaccine recipients; this work further extends the experience of a long-term protective efficacy of the vaccine. |
| Databáze: | OpenAIRE |
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