Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation, enhancing oxidative status in dyslipidemic patients from the area of Rabat (Morocco)

Autor: Virginie Mimouni, Adil Haimeur, Azelarab Masrar, Nadia Meskini, Hafida Messaouri, Lionel Ulmann, Abdelmjid Chraibi, Gérard Tremblin
Přispěvatelé: Laboratoire de Virologie, Microbiologie, Qualité/Ecotoxicologie et Biodiversité, IUT de Laval, Le Mans Université (UM), Mer, molécules et santé EA 2160 (MMS), Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN)
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Platelet Aggregation
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Argan oil
030204 cardiovascular system & hematology
medicine.disease_cause
0302 clinical medicine
Endocrinology
Hyperlipidemia
ComputingMilieux_MISCELLANEOUS
0303 health sciences
Middle Aged
Lipids
3. Good health
Morocco
Cholesterol
Female
Lipidology
Adult
medicine.medical_specialty
food.ingredient
Clinical chemistry
Context (language use)
[SDV.CAN]Life Sciences [q-bio]/Cancer
Clinical nutrition
03 medical and health sciences
food
Internal medicine
medicine
Humans
Plant Oils
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
030304 developmental biology
Dyslipidemias
Biochemistry
medical
Sapotaceae
business.industry
Research
Biochemistry (medical)
Cholesterol
HDL
Thrombosis
Cholesterol
LDL
medicine.disease
Atherosclerosis
Oxidative Stress
Dyslipidemia
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Oxidative stress
Zdroj: Lipids in Health and Disease
Lipids in Health and Disease, BioMed Central, 2013, 12 (1), pp.107. ⟨10.1186/1476-511X-12-107⟩
ISSN: 1476-511X
DOI: 10.1186/1476-511X-12-107⟩
Popis: Background It is now established that patients with hyperlipidemia have a high risk of atherosclerosis and thrombotic complications, which are two important events responsible for the onset and progression of cardiovascular disease. In the context of managing dyslipidemia by means of dietary advice based on the consumption of argan oil, we wanted to investigate the effect of virgin argan oil on plasma lipids, and for the first time, on the platelet hyperactivation and oxidative status associated with dyslipidemia. This study concerns patients recruited in the area of Rabat in Morocco. Methods 39 dyslipidemic (79% women) patients were recruited for our study in the area of Rabat in Morocco. They were randomly assigned to the two following groups: the argan group, in which the subjects consumed 25 mL/day of argan oil at breakfast for 3 weeks, and the control group in which argan oil was replaced by butter. Results After a 3-week consumption period, blood total cholesterol was significantly lower in the argan oil group, as was LDL cholesterol (23.8% and 25.6% lower, respectively). However, the HDL cholesterol level had increased by 26% at the end of the intervention period compared to baseline. Interestingly, in the argan oil group thrombin-induced platelet aggregation was lower, and oxidative status was enhanced as a result of lower platelet MDA and higher GPx activity, respectively. Conclusions In conclusion, our results, even if it is not representative of the Moroccan population, show that argan oil can prevent the prothrombotic complications associated with dyslipidemia, which are a major risk factor for cardiovascular disease.
Databáze: OpenAIRE
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