Autoantibodies against four-and-a-half-LIM domain 1 (FHL1) in inflammatory myopathies: results from an Australian single-centre cohort
| Autor: | Angeles S Galindo-Feria, Begum Horuluoglu, Jessica Day, Catia Fernandes-Cerqueira, Edvard Wigren, Susanne Gräslund, Susanna Proudman, Ingrid E Lundberg, Vidya Limaye |
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| Přispěvatelé: | Galindo-Feria, Angeles S, Horuluoglu, Begum, Day, Jessica, Fernandes-Cerqueira, Catia, Wigren, Edvard, Graslund, Susanne, Proudman, Susanna, Lundberg, Ingrid E, Limaye, Vidya |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Myositis
PM Australia Intracellular Signaling Peptides and Proteins Muscle Proteins LIM Domain Proteins myositis-specific autoantibodies anti-FHL1 autoantibodies Autoantigens IBM Cohort Studies myositis-associated autoantibodies Rheumatology DM Humans Pharmacology (medical) SSc Autoantibodies HLA-DRB1 Chains |
| Zdroj: | Rheumatology |
| Popis: | Objectives To determine the prevalence and associations of autoantibodies targeting a muscle-specific autoantigen, four-and-a-half-LIM-domain 1 (FHL1), in South Australian patients with histologically-confirmed idiopathic inflammatory myopathies (IIM) and in patients with SSc. Material and methods Sera from patients with IIM (n = 267) from the South Australian Myositis Database (SAMD), SSc (n = 174) from the Australian Scleroderma Cohort Study (ASCS) and healthy controls (HC, n = 100) were analysed for anti-FHL1 autoantibodies by Enzyme-Linked ImmunoSorbent Assay (ELISA). Results Autoantibodies to FHL1 were more frequent in patients with IIM (37/267, 13.8%) compared with SSc (12/174, 7%) (P Conclusions We report a substantial prevalence (13.8%) of anti-FHL1 autoantibodies in a large cohort of patients with histologically confirmed IIM; 75% of these cases did not have a detectable myositis-specific autoantibody. Anti-FHL1 autoantibodies were also detected in a subgroup of patients with SSc (7%), indicating that anti-FHL1 autoantibodies may not be myositis-specific. The trend towards an HLA-DR association might indicate a specific immune response to the FHL1 protein. |
| Databáze: | OpenAIRE |
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