In vitro inhibition of the rate of erythrocyte sickling by RMI 11,071A and its possible mechanism
| Autor: | G L Schatzman, M J Cawein, R D Mackenzie, E M Gleason |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Ionophores chemistry.chemical_element Erythrocytes Abnormal Oxygen–haemoglobin dissociation curve Anemia Sickle Cell Azepines Calcium In Vitro Techniques Antisickling agents Oxygen General Biochemistry Genetics and Molecular Biology pCO2 In vitro chemistry Biochemistry Antisickling Agents In vitro system Stilbenes Biophysics Humans Imines Deoxygenation |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 162(1) |
| ISSN: | 0037-9727 |
| Popis: | SummaryRMI 11,071 A, one of a series of lactamimides, was found to inhibit the sick-ling rate in an in vitro system. This inhibition was not total or permanent; the sickling rate increased after 30 min at low O2 tension and the number of sickled cells approached that of the controls by 60 min. There was no effect on pH, pCO2, or the oxygen dissociation curve. 45Ca fluxes were affected. Though influx of 45Ca increased on deoxygenation, the compound caused a decrease in 45Ca content on reoxygenation. This decrease was absent in the control group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|