Acceptability of Cell and Gene Therapy for Curing HIV Infection Among People Living with HIV in the Northwestern United States: A Qualitative Study
| Autor: | Laurie Sylla, Hursch Patel, Stuart Luter, Zahra H Mohamed, Jane M. Simoni, Michael Louella, Karine Dubé, Ann C. Collier |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Health Knowledge Attitudes Practice Northwestern United States Genetic enhancement Immunology Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Sociobehavioral Studies 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Acquired immunodeficiency syndrome (AIDS) Virology medicine Humans 030212 general & internal medicine Qualitative Research Aged Community engagement business.industry Focus Groups Middle Aged medicine.disease Focus group Biological Therapy 030104 developmental biology Infectious Diseases Family medicine Female Thematic analysis business Qualitative research |
| Zdroj: | AIDS Res Hum Retroviruses |
| Popis: | Multiple strategies to cure HIV infection are under investigation, including cell and gene therapy (C>) approaches. Research, and ultimately treatment, with these novel strategies will require patients' willingness to participate. To elicit the perspectives of people living with HIV specific to these novel approaches, we conducted 4 focus group discussions with a diverse group of 19 English-speaking men and women living with HIV in care at a large academic HIV clinic in the northwestern United States. Thematic analysis indicated participants expressed initial fear about C> research. They articulated specific concerns about risks, including analytical treatment interruptions, and thought only a person in desperate straits would participate. They voiced significant mistrust of research in general and believed there was already a cure from HIV that was being withheld from the poor. Overall, they were satisfied with their health and quality of life on antiretroviral therapy. These findings suggest the importance of community engagement and educational efforts about C> for HIV cure to ensure optimal collaborative partnerships. |
| Databáze: | OpenAIRE |
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