Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents

Autor:	Francisco-J. Gamo, Diver Sellanes, Laura M. Sanz, Anna Caroline Campos Aguiar, Elizabeth A. Winzeler, Catherine Fagundez, Stella Peña, Vanessa Yardley, Juliana Oliveira de Souza, Rafael Victorio Carvalho Guido, Gloria Serra, Laura Scarone, Lindsay B. Stewart, Sabine Ottilie
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Liver stage chemistry.chemical_classification 010405 organic chemistry Chemistry PLANEJAMENTO DE FÁRMACOS Organic Chemistry 01 natural sciences Biochemistry In vitro 0104 chemical sciences Amino acid 010404 medicinal & biomolecular chemistry Pharmacokinetics In vivo Drug Discovery Gene
Zdroj:	Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP
Popis:	[Image: see text] Malaria is a major tropical disease where important needs are to mitigate symptoms and to prevent the establishment of infection. Cyclopeptides containing N-methyl amino acids with in vitro activity against erythrocytic forms as well as liver stage are presented. The synthesis, parasitological characterization, physicochemical properties, in vivo evaluation, and mice pharmacokinetics are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d138e287cb4e19568d42017733795a https://europepmc.org/articles/PMC6331169/ Zobrazit plný text záznamu