Effects of bilobalide on amino acid release and electrophysiology of cortical slices
| Autor: | F. A. Jones, S. S. Chatterjee, J. A. Davies |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
N-Methylaspartate
Clinical Biochemistry Nipecotic Acids Glutamic Acid Cyclopentanes In Vitro Techniques Biochemistry Mice chemistry.chemical_compound Bilobalide Oximes Animals Magnesium Neurotransmitter Uptake Inhibitors Furans Cerebral Cortex chemistry.chemical_classification Aspartic Acid Mice Inbred BALB C Neurotransmitter Agents Veratridine Chemistry Organic Chemistry Glutamate receptor Amino acid Electrophysiology Ginkgolides Mice Inbred DBA Amino acid neurotransmitter Potassium Biophysics Excitatory postsynaptic potential NMDA receptor Diterpenes |
| Zdroj: | Amino Acids. 22:369-379 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/s007260200021 |
| Popis: | This study investigated the effects of bilobalide, a constituent of Ginkgo biloba, on potassium and veratridine-induced release of glutamate and aspartate from mouse cortical slices. We also studied its effects on spontaneous and N-methyl-D-aspartate (NMDA)-induced depolarizations elicited in magnesium-free artificial cerebrospinal fluid (aCSF) as well as its effect on NO-711 (a gamma-aminobutyric acid (GABA) uptake inhibitor)-induced depolarizations. Bilobalide, 100 microM significantly reduced both glutamate and aspartate release elicited by potassium or veratridine. Bilobalide (5-100 microM) also significantly reduced the frequency of NO-711 induced depolarizations, however, it had no effect on spontaneous or on NMDA-induced depolarizations at 5-200 microM. These results suggest that the neuroactive properties of bilobalide may be mediated by a reduction in excitatory amino acid neurotransmitter release. |
| Databáze: | OpenAIRE |
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