Development of a Universal Colorimetric Indicator for G-Quadruplex Structures by the Fusion of Thiazole Orange and Isaindigotone Skeleton
| Autor: | Ding Li, Wen-Jie Ye, Jia-Heng Tan, Jin-Qiang Hou, Jin-wu Yan, Wei-Bin Wu, Lian-Quan Gu, Shuo-Bin Chen, Tian-Miao Ou, Zhi-Shu Huang |
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| Rok vydání: | 2012 |
| Předmět: |
Fusion
Isaindigotone Specific detection Stereochemistry Chemistry Skeleton (category theory) G-quadruplex Thiazole orange Combinatorial chemistry Analytical Chemistry G-Quadruplexes Alkaloids Universal indicator Visual detection Fluorescence Resonance Energy Transfer Quinazolines Quinolines Colorimetry Indicators and Reagents Benzothiazoles |
| Zdroj: | Analytical Chemistry. 84:6288-6292 |
| ISSN: | 1520-6882 0003-2700 |
| DOI: | 10.1021/ac300207r |
| Popis: | The rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color change enables label-free visual detection of G-quadruplexes, which is due to the disassembly of dye H-aggregates to monomers. This specific detection of G-quadruplex arises from its end-stacking interaction with G-quartet. On the basis of this universal indicator, a facile approach for large-scale identification of G-quadruplex was developed. |
| Databáze: | OpenAIRE |
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