Pharmacological Activity of Deep-Sea Water: Examination of Hyperlipemia Prevention and Medical Treatment Effect
| Autor: | Yutaka Nishioka, Atsuhide Hamada, Ichiro Odani, Sayaka Yamamoto, Saburo Yoshioka, Yasuyuki Tsutsui, Tailin Cui, Kazuhiro Odani, Masahiko Kusunose, Mitsuhiko Miyamura, Junko Yokota, Shojiro Kyotani, Ryou Kaneda |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Lipoproteins Pharmaceutical Science Low density lipoprotein cholesterol Hyperlipidemias Cholesterol Dietary chemistry.chemical_compound High-density lipoprotein Internal medicine Total cholesterol medicine Animals Seawater Pharmacology Lagomorpha biology Triglyceride Cholesterol Biological activity General Medicine biology.organism_classification Endocrinology chemistry Distilled water lipids (amino acids peptides and proteins) Rabbits |
| Zdroj: | Biological and Pharmaceutical Bulletin. 26:1552-1559 |
| ISSN: | 1347-5215 0918-6158 |
| Popis: | When normal rabbits were administered various samples of deep-sea water, their biochemical values changed within normal limits, and no differences from distilled water administration (control) group levels were observed. Furthermore, no histopathological changes were observed in internal organs on the 28th day after administration. The serum total cholesterol (T-Cho) and low density lipoprotein cholesterol (LDL-Cho) levels of normal rabbits fed with a 1% cholesterol-containing diet simultaneously administered deep-sea water (desalinated water, hardness 28, 300, and 1200) increased with time up to about 1500 mg/dl. However, the degrees of increase were smaller than those of the control group, which received distilled water. Furthermore, when prepared hyperlipemia rabbits were administered deep-sea water (desalinated water, hardness 28, 300, and 1200), there were no significant changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), high density lipoprotein cholesterol (HDL-Cho), or triglyceride (TG) levels. On the other hand, T-Cho and LDL-Cho levels were reduced when the rabbits were changed to normal food, and the degree of reduction was more than that of the control group. In the liver and main artery bow, as the hardness of the deep-sea water increased, the accumulation of lipid and permeation of macrophages was reduced. This result was well in agreement with the results of the T-Cho and LDL-Cho levels. From these results, it is clear that deep-sea water controls the increase of serum lipid values (T-Cho and LDL-Cho) of cholesterol-fed rabbits, and promotes the reduction of serum lipid hyperlipemia rabbits. The minerals in deep-sea water greatly influence this effect. |
| Databáze: | OpenAIRE |
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