Sero-Prevalence of Rodent Pathogens in India
| Autor: | Nagendra R. Hegde, Prachet G. Kulkarni, Shrruthi Manjunath, Ramachandra Subbaraya Gudde, Krishnaveni Nagavelu, Nandhini Ramasamy, Rosa J. Samuel, Sandhya Srinivasan |
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| Rok vydání: | 2014 |
| Předmět: |
viruses
lcsh:Medicine India Enzyme-Linked Immunosorbent Assay Lymphocytic choriomeningitis medicine.disease_cause Antibodies Viral Virus Microbiology Mycoplasma pulmonis Rodent Diseases Mice Mouse hepatitis virus Seroepidemiologic Studies Animals Laboratory medicine Prevalence Animals Mycoplasma Infections lcsh:Science Multidisciplinary biology Geography Ectromelia virus Incidence lcsh:R virus diseases Mycoplasma biology.organism_classification medicine.disease Virology Antibodies Bacterial Sendai virus Rats Virus Diseases Viruses lcsh:Q Minute virus of mice Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 7, p e0131706 (2015) |
| ISSN: | 1932-6203 |
| Popis: | Health monitoring is an integral part of laboratory animal quality standards. However, current or past prevalence data as well as regulatory requirements dictate the frequency, type and the expanse of health monitoring. In an effort to understand the prevalence of rodent pathogens in India, a preliminary study was carried out by sero-epidemiology. Sera samples obtained from 26 public and private animal facilities were analyzed for the presence of antibodies against minute virus of mice (MVM), ectromelia virus (ECTV), lymphocytic choriomeningitis virus (LCMV), mouse hepatitis virus (MHV), Sendai virus (SeV), and Mycoplasma pulmonis in mice, and SeV, rat parvo virus (RPV), Kilham's rat virus (KRV) and sialodacryoadenitis virus (SDAV) in rats, by sandwich ELISA. It was observed that MHV was the most prevalent agent followed by Mycoplasma pulmonis and MVM in mice, and SDAV followed by RPV were prevalent in rats. On the other hand, none of the samples were positive for ECTV in mice, or SeV or KRV in rats. Multiple infections were common in both mice and rats. The incidence of MHV and Mycoplasma pulmonis was higher in facilities maintained by public organizations than in vivaria of private organizations, although the difference was not statistically different. On the other hand the prevalence of rodent pathogens was significantly higher in the northern part of India than in the South. These studies form the groundwork for detailed sero-prevalence studies which should further lay the foundations for country-specific guidelines for health monitoring of laboratory animals. |
| Databáze: | OpenAIRE |
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