Inspiratory Muscle Weakness is Associated With Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction: A Preliminary Study
| Autor: | Takeshi Sota, Mari Miyagi, Shinobu Sugihara, Kazuhiro Yamamoto, Yoshiharu Kinugasa, Masahiko Kato, Kensaku Yamada |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Weakness medicine.medical_specialty Diaphragm Nutritional Status Exercise intolerance 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Aged Ultrasonography Aged 80 and over Heart Failure Exercise Tolerance Muscle Weakness business.industry Skeletal muscle Muscle weakness Stroke Volume Stroke volume medicine.disease Diaphragm (structural system) Respiratory Function Tests medicine.anatomical_structure Heart failure Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine Heart failure with preserved ejection fraction business |
| Zdroj: | Journal of cardiac failure. 22(1) |
| ISSN: | 1532-8414 |
| Popis: | The relationship between inspiratory muscle weakness (IMW) and exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF) remains unestablished.The present study enrolled 40 patients with HFpEF (EF ≥45%). IMW was defined as maximum inspiratory pressure70% normal predicted values. The function of the diaphragm was assessed by means of ultrasound measurement of muscle thickening of the diaphragm. IMW was prevalent in 27.5% of patients. Patients with IMW had significantly lower vital capacity relative to normal predicted values (%VC), lower knee extensor muscle strength in relation to body weight (%KEMS), poorer nutritional status as assessed by means of the Geriatric Nutritional Risk Index, and shorter 6-minute walk distance (6MWD) compared with patients without IMW (all P .05). Impaired diaphragm muscle thickening at end-inspiration (median value 3.9 mm) was significantly associated with a high prevalence of IMW and reduced 6MWD (all P .05). Subgroup analysis showed that IMW was accompanied by a further decrease in 6MWD in patients with restrictive pulmonary dysfunction (%VC80%) or lower-limb muscle weakness (median %KEMS30%; all P .05).IMW is associated with exercise intolerance in patients with HFpEF. |
| Databáze: | OpenAIRE |
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