Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
| Autor: | Dariush Elahi, Lazaros A. Nikolaidis, Sunil Mankad, Richard P. Shannon, George G. Sokos, Ankur Shah, Glen Miske |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Heart disease medicine.medical_treatment Glucose uptake Glucagon-Like Peptides Myocardial Infarction Incretin Pilot Projects Ventricular Function Left Diabetes Complications Glucagon-Like Peptide 1 Physiology (medical) Angioplasty Internal medicine medicine Humans Myocardial infarction Angioplasty Balloon Coronary Aged Aged 80 and over Ejection fraction business.industry Stroke Volume Middle Aged medicine.disease Glucagon Combined Modality Therapy Peptide Fragments Treatment Outcome Heart failure Cardiology Myocardial infarction complications Female Safety Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 109(8) |
| ISSN: | 1524-4539 |
| Popis: | Background— Glucose-insulin-potassium infusions are beneficial in uncomplicated patients with acute myocardial infarction (AMI) but are of unproven efficacy in AMI with left ventricular (LV) dysfunction because of volume requirements associated with glucose infusion. Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties that stimulate glucose uptake without the requirements for concomitant glucose infusion. Methods and Results— We investigated the safety and efficacy of a 72-hour infusion of GLP-1 (1.5 pmol/kg per minute) added to background therapy in 10 patients with AMI and LV ejection fraction (EF) P P P Conclusions— When added to standard therapy, GLP-1 infusion improved regional and global LV function in patients with AMI and severe systolic dysfunction after successful primary angioplasty. |
| Databáze: | OpenAIRE |
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