Pancreas transplantation using compatible but non-identical ABO blood group donors
| Autor: | John A. Powelson, Santosh Nagaraju, Jonathan A. Fridell, Richard S. Mangus |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment 030204 cardiovascular system & hematology 030230 surgery Pancreas transplantation Gastroenterology ABO Blood-Group System 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine Lactate dehydrogenase ABO blood group system medicine Living Donors Humans In patient Retrospective Studies Blood type Transplantation business.industry Incidence (epidemiology) Graft Survival Middle Aged medicine.disease Prognosis Hemolysis medicine.anatomical_structure chemistry Histocompatibility Female Pancreas Transplantation business Pancreas Follow-Up Studies |
| Zdroj: | Clinical transplantation. 32(7) |
| ISSN: | 1399-0012 |
| Popis: | BACKGROUND There are limited data on the outcomes of pancreas transplants using ABO non-identical but compatible (NIC) donors. METHODS A review of all pancreas transplants from a single institution from 01/2003 to 07/2016 (n = 606) revealed 41 recipients of a NIC donor pancreas which were matched for age, race, gender, year, and type of transplant with 41 ABO identical cases. Groups were compared for allograft survival, incidence of acute cellular rejection (ACR), length of hospital stay, 3-month readmissions and transfusion requirements. Serum haptoglobin and lactate dehydrogenase were used to identify hemolysis in patients requiring repeated transfusions without overt blood loss. RESULTS The 1-year graft survival was 100% and 88% in the study and control groups. In the study group, 6/41(14%) developed hemolysis, all of which were ABO O into A. All responded to donor blood type specific transfusions. DISCUSSION There are limited data on outcomes of solid organ transplant using NIC donors with almost none specifically addressing pancreas transplantation. In this study, graft survival was similar but 14% developed hemolysis, which was transient and treated with transfusion of donor blood type specific blood. CONCLUSION Non-identical but compatible pancreas transplants have similar graft survival compared to ABO identical. Hemolysis may occur so some caution is required. |
| Databáze: | OpenAIRE |
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