Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells

Autor:	Stephanie A. Luff, J. Philip Creamer, Sara Valsoni, Carissa Dege, Rebecca Scarfò, Analisa Dacunto, Sara Cascione, Lauren N. Randolph, Eleonora Cavalca, Ivan Merelli, Samantha A. Morris, Andrea Ditadi, Christopher M. Sturgeon
Rok vydání:	2021
Předmět:	Pluripotent Stem Cells animal structures single-cell RNA-seq Bioinformatics Hemangioblasts Cell Differentiation Tretinoin Cell Biology Hematopoiesis Pregnancy embryonic structures Humans Cell Lineage Female
Zdroj:	Nature cell biology 24 (2022): 616–+. doi:10.1038/s41556-022-00898-9 info:cnr-pdr/source/autori:Luff, Stephanie A.; Creamer, J. Philip; Valsoni, Sara; Dege, Carissa; Scarfo, Rebecca; Dacunto, Analisa; Cascione, Sara; Randolph, Lauren N.; Cavalca, Eleonora; Merelli, Ivan; Morris, Samantha A.; Ditadi, Andrea; Sturgeon, Christopher M./titolo:Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells/doi:10.1038%2Fs41556-022-00898-9/rivista:Nature cell biology/anno:2022/pagina_da:616/pagina_a:+/intervallo_pagine:616–+/volume:24
ISSN:	1476-4679
DOI:	10.1038/s41556-022-00898-9
Popis:	The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. During embryonic development, HSCs derive from haemogenic endothelium (HE) in a NOTCH- and retinoic acid (RA)-dependent manner. Although a WNT-dependent (WNTd) patterning of nascent hPSC mesoderm specifies clonally multipotent intra-embryonic-like HOXA
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c7a8059e84cddfa73f22fec5797134 https://pubmed.ncbi.nlm.nih.gov/35484246 Zobrazit plný text záznamu Full text from SpringerLink