Expansion and diversification of the signaling capabilities of the CD2/SLAM family in Xenopodinae amphibians
| Autor: | Petr P. Laktionov, Alexander M. Najakshin, Sergey V. Guselnikov, Alexander V. Taranin, Konstantin O Baranov |
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| Rok vydání: | 2010 |
| Předmět: |
Genetics
biology Phylogenetic tree Xenopus Immunology Molecular Sequence Data CD2 Antigens Receptors Cell Surface biology.organism_classification Genome Evolution Molecular Signaling Lymphocytic Activation Molecule Family Member 1 Phylogenetics Antigens CD Complementary DNA Animals Amino Acid Sequence Receptor Gene Sequence Alignment Phylogeny Silurana Signal Transduction |
| Zdroj: | Immunogenetics. 63(10) |
| ISSN: | 1432-1211 |
| Popis: | We studied the evolution of the CD2 family in tetrapods by extracting and analyzing CD2-like genes from the genome of the amphibian species Silurana (Xenopus) tropicalis. An exhaustive analysis of the genomic and cDNA databases resulted in the identification of at least 70 CD2-like genes. The predicted receptors mostly maintain the typical VC2 ectodomains, but are highly diverse in their C-termini, which suggests a broad range of signaling capacities. Apart from the presumed monomeric receptors with ITSM and/or ITIM motifs, the Silurana family includes secreted proteins. Furthermore, a fraction of the receptors contain a conserved TM subtype with the NxxR motif that is known to promote an association with the FcRγ subunit and that was previously found in the members of the FcR- and KIR-related receptors. The expression analysis of a sample of the genes showed broad tissue distribution and gene-specific expression patterns. Phylogenetic analysis predicted that the CD58, CD150/SLAM, and SLAMF8 genes were maintained as single-copy genes in both mammals and amphibians, while others expanded/contracted in a lineage-specific manner. |
| Databáze: | OpenAIRE |
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