Comparative study of IgG binding to megakaryocytes in immune and myelodysplastic thrombocytopenic patients
| Autor: | Esmat A El Sharkawi, Aliaa S Abd El-Fatah, Waleed M Abd El-Hamed, Doaa I. Elzaeem, Ayman G Ghobrial, Eman Mosaad Zaki |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia Megaloblastic Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Immune system In vivo Bone Marrow hemic and lymphatic diseases Internal medicine medicine Humans Platelet Autoantibodies Purpura Thrombocytopenic Idiopathic Hematology business.industry Myelodysplastic syndromes Autoantibody Anemia Aplastic General Medicine Middle Aged medicine.disease Thrombocytopenia medicine.anatomical_structure Cross-Sectional Studies IgG binding 030220 oncology & carcinogenesis Immunoglobulin G Myelodysplastic Syndromes Female Bone marrow business Megakaryocytes 030215 immunology |
| Zdroj: | Annals of hematology. 100(7) |
| ISSN: | 1432-0584 |
| Popis: | Immune thrombocytopenia (ITP) is a disorder in which autoantibodies are responsible for destruction and decreased production of platelets. In the meantime, thrombocytopenia is frequent in patients with myelodysplastic syndromes (MDS) and immune clearance of megakaryocytes could be a reason. The aim of the present study is to evaluate and compare IgG binding to megakaryocytes in bone marrow of ITP and MDS patients to determine megakaryocytes targeting by autoantibodies in vivo as a mechanism of platelet underproduction in these disorders. The study was carried out on 20 ITP (group I) patients, 20 thrombocytopenic patients with (MDS) (group II), and 20 non-ITP patients as a control (group III) who were admitted to Minia University Hospital. Serial histological sections from bone marrow biopsies were stained for IgG. All patients in group I and 50% of group II patients showed bleeding tendency and the difference was significant (p |
| Databáze: | OpenAIRE |
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