From word reading to multisentence comprehension: Improvements in brain activity in children with autism after reading intervention
| Autor: | Donna L. Murdaugh, Rajesh K. Kana, Jose O. Maximo, Claire E. Cordes, Sarah O'Kelley |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
genetic structures Brain activity and meditation SORT-R Slosson Oral Reading Test - Revised WASI Wechsler Abbreviated Scale of Intelligence Audiology ASD-WLC children with ASD in the waitlist control group lcsh:RC346-429 Dyslexia 0302 clinical medicine Reading (process) Child ASD-EXP children with ASD in the treatment group media_common Brain Mapping ADOS Autism Diagnostic Observation Schedule fMRI 05 social sciences Regular Article LMFG left middle frontal gyrus Neurology fMRI functional magnetic resonance imaging GORT-4 Gray Oral Reading Test – Fourth Edition lcsh:R858-859.7 Female LSMA left supplementary motor area Comprehension Psychology psychological phenomena and processes Cognitive psychology medicine.medical_specialty ASD autism spectrum disorder LIFG left inferior frontal gyrus Adolescent LFFG left fusiform gyrus Cognitive Neuroscience media_common.quotation_subject Posterior parietal cortex Neuroimaging Intervention lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities 050105 experimental psychology LTHAL left thalamus 03 medical and health sciences mental disorders medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Autistic Disorder ADI Autism Diagnostic Interview-Revised Children with ASD lcsh:Neurology. Diseases of the nervous system LPCG left precentral gyrus Fusiform gyrus LSTG left superior temporal gyrus Postcentral gyrus V/V Visualizing and Verbalizing Precentral gyrus LIOG left inferior occipital gyrus Reading comprehension medicine.disease LSPL left superior parietal lobule Reading Neurology (clinical) 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 16, Iss, Pp 303-312 (2017) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2017.08.012 |
| Popis: | Background: Children with ASD show a unique reading profile characterized by decoding abilities equivalent to verbal abilities, but with lower comprehension skills. Neuroimaging studies have found recruitment of regions primarily associated with visual processing (e.g., fusiform gyrus and medial parietal cortex), but reduced activation in frontal and temporal regions, when reading in adults with ASD. The purpose of this study was to assess neural changes associated with an intense reading intervention program in children with ASD using three fMRI tasks of reading. Methods: 25 children with ASD were randomly assigned to a treatment (ASD-EXP) or waitlist group (ASD-WLC). Children participated in a reading intervention program (4-hour sessions per day, 5days a week for 10weeks). We utilized three tasks: word, sentence, and multisentence processing, each with differential demands of reading comprehension. fMRI data were acquired at each of two scanning sessions 10-weeks apart. Results: Across tasks, post-intervention results revealed that the ASD-EXP group showed greater activation in bilateral precentral gyrus and the postcentral gyrus, visual processing regions (e.g., occipital cortex, fusiform gyrus), and frontal regions. In the word task, left thalamus and the right angular gyrus (AG) activation was unique to the ASD-EXP group post-intervention. Sentence tasks showed differential activation of core language areas (e.g., IFG, IPL) post-intervention. Conclusions: Our results provide evidence for differential recruitment of brain regions based on task demands in children with ASD, and support the potential of targeted interventions to alter brain activation in response to positive gains in treatment. Children with ASD have a different reading profile from other reading disorders that needs to be specifically targeted in interventions. Keywords: Intervention, Children with ASD, fMRI, Reading comprehension |
| Databáze: | OpenAIRE |
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