Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema
| Autor: | Paulo Roberto Stefani Sanches, Guilherme Eckert Peterson, Samanta Sarmento da Silva, Eliane Roesch, José Carlos Soares de Fraga, Jane Maria Ulbrich, Patrícia Miorelli, Sergio Luis Amantea |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
RD1-811 Pleural effusion medicine.medical_treatment Turpentine Thoracentesis medicine.disease_cause Andrology Transforming Growth Factor beta1 03 medical and health sciences Empiema pleural 0302 clinical medicine Streptococcus pneumoniae medicine Animals Fator de crescimento transformador beta1 Rats Wistar Empyema Pleural Bacteria Chemistry Pleural empyema Rats Citocinas medicine.disease Empyema Pleural Effusion Disease Models Animal 030228 respiratory system Staphylococcus aureus 030220 oncology & carcinogenesis Transforming growth factor beta 1 Cytokines Surgery Biomarkers Transforming growth factor |
| Zdroj: | Acta Cirúrgica Brasileira v.33 n.2 2018 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Acta Cirurgica Brasileira, Volume: 33, Issue: 2, Pages: 156-162, Published: FEB 2018 Acta Cirurgica Brasileira, Vol 33, Iss 2, Pp 156-162 (2018) |
| Popis: | Purpose: To evaluate the concentration of transforming growth factor beta 1 (TGFB1) levels in a rat pleural effusion obtained by inoculation of intrapleural bacteria or turpentine through thoracentesis. Methods: Thirty-Nine Wistar rats were divided into three groups: Staphylococcus aureus (SA, n = 17); Streptococcus pneumoniae (SP, n = 12); and turpentine (control, n = 10). Pleural fluid was collected through ultrasound-guided thoracentesis 12 h, 24 h, and 36 h after instillation of bacteria or turpentine. Levels of TGFB1 were measured in pleural fluid. Results: At 12 h, mean TGFB1concentrations were 5.3450 pg/mL in the SA group, 5.3449 pg/mL in the SP group, and 5.3450 pg/mL in controls. At 24 h, they were 4.6700 pg/mL in the SA group, 4.6700 pg/mL in the SP group, and 4.6700 pg/mL in controls. At 36 h, they were 4.6699 pg/mL in the SA group and in control. No difference was observed among the groups in mean TGFB1concentration (p = 0.12); however, a significant intragroup reduction in mean TGFB1 was observed between 12 and 24 h (p < 0.01). Conclusion: The transforming growth factor beta 1 concentrations were not useful as a diagnostic tool or an early marker of infected pleural effusion. |
| Databáze: | OpenAIRE |
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