Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice
| Autor: | Bin Bao, Jing Dong, Jian Liu, Na Xu, Xian Zhang, Yan-Guang Chen, Lei Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Down-Regulation Adipose tissue Apoptosis Bone Marrow Cells Diet High-Fat Weight Gain Mice chemistry.chemical_compound Insulin resistance Internal medicine Diabetes mellitus Adipocytes medicine Animals Mast Cells Obesity Mast cell stabilizer Luteolin Inflammation Interleukin-6 Tumor Necrosis Factor-alpha business.industry medicine.disease Mast cell Cathepsins Mice Inbred C57BL PPAR gamma Cytokine Endocrinology medicine.anatomical_structure Adipose Tissue chemistry Dietary Supplements Insulin Resistance business Signal Transduction Food Science Biotechnology |
| Zdroj: | Molecular Nutrition & Food Research. 58:1258-1268 |
| ISSN: | 1613-4125 |
| DOI: | 10.1002/mnfr.201300830 |
| Popis: | cope Mast cells play important roles in diet-induced obesity and diabetes, and some synthetic mast cell stabilizers can improve related metabolic disturbances in mice. Luteolin (LU) is a potent natural mast cell stabilizer. However, a direct correlation between LU and these common metabolic diseases is not established. Methods and results Male C57BL/6 mice were fed low-fat diet, high-fat diet (HFD), HFD with 0.002 and 0.01% LU for 12 wk, respectively. Dietary LU suppressed HFD-induced body weight gain, fat deposition, and adipocyte hypertrophy. Meanwhile, glucose intolerance and insulin sensitivity was also improved. Interestingly, dietary LU ameliorated angiogenesis and associated cell apoptosis and cathepsin activity in epididymis adipose tissues, which is a critical mechanism that mast cells are involved in diet-induced obesity and diabetes. Further, we showed dietary LU reduced mast cell and macrophage infiltrations and inflammatory cytokine levels in epididymis adipose tissues. Finally, LU inhibited mast cell-derived IL-6 expression, which is a key cytokine that contributes to mast cell-associated metabolic derangements, and protein kinase C activator phorbol myristoyl acetate reversed the inhibitory effects. Conclusions As a natural flavonoid, low-dose diet supplement of LU ameliorates diet-induced obesity and insulin resistance in mice, suggesting a new therapeutic and interventional approach for these diseases. |
| Databáze: | OpenAIRE |
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