6-(Bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms
| Autor: | Thavendran Govender, Fernando Albericio, Prabhakar Cherkupally, Beatriz G. de la Torre, Suhas Ramesh, Hendrik G. Kruger |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Molecular Structure Stereochemistry Organic Chemistry Peptide Stereoisomerism Conjugated system Biochemistry chemistry.chemical_compound chemistry Thioether Dendrimer Molecule Moiety Amino Acid Sequence Physical and Theoretical Chemistry Peptides Caproates Nuclear Magnetic Resonance Biomolecular Ene reaction |
| Zdroj: | Organic letters. 17(3) |
| ISSN: | 1523-7052 |
| Popis: | We report on a novel and user-friendly platform based on a bromomaleimide moiety to obtain branched peptides. The platform is stable for all SPPS conditions. The bromomaleimide core was conjugated to n-copies of thiol-peptide in-solution to obtain two/four/eight-armed dendrimers. Using 'n' number of bromomaleimide analogues, 2(n) ligands were incorporated at both bromo and ene positions via a thioether bond. This method has the advantage of high conversion in a short time, thus enabling effortless purification and characterization processes. |
| Databáze: | OpenAIRE |
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