Isolation of a hagfish gene that encodes a complement component
| Autor: | Kazuto Kobayashi, K. Titani, Hiroshi Ishiguro, Motoshi Suzuki, Yoshikazu Kurosawa, S. Tomonaga |
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| Rok vydání: | 1992 |
| Předmět: |
Molecular Sequence Data
Restriction Mapping Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Restriction map Molecular evolution Sequence Homology Nucleic Acid biology.animal Complementary DNA Eptatretus burgeri Animals Amino Acid Sequence Molecular Biology Gene Peptide sequence Genetics Base Sequence General Immunology and Microbiology biology General Neuroscience Nucleic acid sequence Complement System Proteins DNA Blotting Northern biology.organism_classification Biological Evolution Blotting Southern RNA Hagfishes Research Article Hagfish |
| Zdroj: | The EMBO Journal. 11:829-837 |
| ISSN: | 0261-4189 |
| DOI: | 10.1002/j.1460-2075.1992.tb05120.x |
| Popis: | It has been widely accepted that cyclostomes are the most primitive vertebrates extant with the ability to produce antibodies. We isolated cDNA clones that encode a putative 'antibody' from one of the cyclostomes, Eptatretus burgeri. The amino acid sequence predicted from the nucleotide sequences of the cDNA clones indicated that this gene does actually encode the proteins isolated as hagfish 'antibodies' by various investigators. However, these proteins are not similar to mammalian immunoglobulins but have some characteristics common to complements C3, C4 and C5 in higher vertebrates. We discuss the relationships of the isolated gene for hagfish complement with the mammalian genes for complements C3, C4 and C5. We also discuss the possibility of the presence of antibodies in cyclostomes. |
| Databáze: | OpenAIRE |
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