Histocompatibility antigens in asthma: population and family studies
| Autor: | M Turner-Warwick, C W Turton, Sylvia D. Lawler, L M Morris, J A Buckingham |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Adolescent Population Human leukocyte antigen Immunoglobulin E Atopy HLA Antigens immune system diseases medicine Humans Child education Aged Asthma education.field_of_study biology business.industry Aspergillosis Allergic Bronchopulmonary Middle Aged medicine.disease Pedigree respiratory tract diseases HLA-A Histocompatibility Immunology biology.protein Female Allergic bronchopulmonary aspergillosis business Research Article |
| Zdroj: | Thorax. 34:670-676 |
| ISSN: | 0040-6376 |
| Popis: | One hundred and twenty-two patients with intrinsic asthma, extrinsic atopic asthma, or asthma with allergic bronchopulmonary aspergillosis were tissue typed for the HLA A, B, and C loci. No associations were found with any of the clinical groups, or with serum total IgE concentrations. Sixty-eight members of 10 families where more than one member was affected by asthma were studied. The segregation of haplotypes in siblings of the propositi who were or were not affected by asthma did not differ from the predicted segregation, and there were no differences when atopy or serum total IgE were considered. No biologically important association between HLA and asthma has been shown. |
| Databáze: | OpenAIRE |
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