Relationship between dosage and response to lithium prophylaxis in recurrent depression
| Autor: | Caffey Em, Prien Rf |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Bipolar Disorder Lithium (medication) Dose-Response Relationship Drug business.industry Depression Lithium carbonate Liter Lithium Middle Aged Gastroenterology Psychiatry and Mental health chemistry.chemical_compound chemistry Recurrence Internal medicine medicine Humans Female Medical prescription business Depression (differential diagnoses) medicine.drug |
| Zdroj: | The American journal of psychiatry. 133(5) |
| ISSN: | 0002-953X |
| Popis: | The authors analyzed the results of a multihospital collaborative study on the effectiveness of lithium prophylaxis in recurrent depression in terms of dosage and found that serum lithium levels between 0.5 and 0.7 mEq/liter and doses below 1000 mg/day were relatively ineffective in preventing recurrences. Serum lithium levels between 0.8 and 1.0 mEq/liter and doses above 1000 mg/day were associated with a relatively low failure rate. The authors discuss the relevance of these findings to current prescription guidelines for lithium carbonate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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