A Generic Approach for the Catalytic Reduction of Nitriles
| Autor: | Duncan B. Judd, Melanie T. Reich, Meredith R. V. Williams, Stephen Caddick, Alexandra K. de K. Lewis |
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| Rok vydání: | 2003 |
| Předmět: |
Organic Chemistry
chemistry.chemical_element Selective catalytic reduction General Medicine Borohydride Biochemistry Chloride Combinatorial chemistry Catalysis Sodium borohydride Nickel chemistry.chemical_compound chemistry Drug Discovery medicine Organic chemistry Selective reduction medicine.drug Nickel boride Excess sodium |
| Zdroj: | ChemInform. 34 |
| ISSN: | 1522-2667 0931-7597 |
| Popis: | The scope of nickel boride mediated reduction of nitriles has been extended further to allow the preparation of Boc protected amines via a mild catalytic process. It is noteworthy that the toxicity of this procedure is greatly reduced due to its catalytic nature in nickel(II) chloride used in combination with excess sodium borohydride. The protocol is marked by its resilience towards air and moisture and hence an easy and general practical protocol. |
| Databáze: | OpenAIRE |
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