Dietary alpha linolenic acid in pregnant mice and during weaning increases brain docosahexaenoic acid and improves recognition memory in the offspring
| Autor: | Daniel Rand, Dana Atrakchi, Michal Schnaider-Beeri, Sigal Liraz-Zaltsman, Kenneth Hollander, Dror Harats, Michal Kandel-Kfir, Yehuda Kamari, Hila Israelov, Itzik Cooper, Hofit Cohen, Alicia Leikin-Frenkel, Aviv Shaish, Orly Ravid |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Docosahexaenoic Acids Offspring Endocrinology Diabetes and Metabolism Clinical Biochemistry Weaning Biology Blood–brain barrier Biochemistry Mice 03 medical and health sciences chemistry.chemical_compound Memory Pregnancy Internal medicine Lactation medicine Animals Molecular Biology chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Fatty acid metabolism alpha-Linolenic acid Brain alpha-Linolenic Acid Fatty acid medicine.disease Mice Inbred C57BL 030104 developmental biology Endocrinology medicine.anatomical_structure Animals Newborn chemistry Docosahexaenoic acid Dietary Supplements Female |
| Zdroj: | The Journal of Nutritional Biochemistry. 91:108597 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/j.jnutbio.2021.108597 |
| Popis: | Docosahexaenoic acid (DHA) is critical for normal brain development and function. DHA is in danger of being significantly reduced in the human food supply, and the question of whether its metabolic precursor, the essential n-3 alpha linolenic acid (ALA) during pregnancy, can support fetal brain DHA levels for optimal neurodevelopment, is fundamental. Female mice were fed either ALA-enriched or Control diet during pregnancy and lactation. The direct effect of maternal dietary ALA on lipids was analyzed in liver, red blood cells, brain and brain vasculature, together with genes of fatty acid metabolism and transport in three-week-old offspring. The long-term effect of maternal dietary ALA on brain fatty acids and memory was studied in 19-week-old offspring. Three-week-old ALA offspring showed higher levels of n-3 fatty acids in liver, red blood cell, blood-brain barrier (BBB) vasculature and brain parenchyma, DHA enrichment in brain phospholipids and higher gene and protein expression of the DHA transporter, major facilitator superfamily domain containing 2a, compared to Controls. 19-week-old ALA offspring showed higher brain DHA levels and better memory performance than Controls. The increased brain DHA levels induced by maternal dietary ALA during pregnancy-lactation, together with the up-regulated levels of major facilitator superfamily domain containing 2a, may indicate a mode for greater DHA uptake with long-term impact on better memory in ALA offspring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect