Oncologic outcomes of transoral robotic surgery for HPV-negative oropharyngeal carcinomas
| Autor: | Bert W. O'Malley, David Shimunov, Ara A. Chalian, Jason G. Newman, Devraj Basu, Gregory S. Weinstein, Steven B. Cannady, John N. Lukens, Charu Aggrawal, Karthik Rajasekaran, Harman S. Parhar, Samuel Swisher-McClure, Robert M. Brody, Roger B. Cohen, Alexander Lin, Joshua Bauml, Christopher H. Rassekh |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Robotic Surgical Procedures Interquartile range Transoral robotic surgery medicine Adjuvant therapy Humans 030223 otorhinolaryngology Retrospective Studies business.industry Head and neck cancer Papillomavirus Infections Neck dissection Perioperative Chemoradiotherapy Adjuvant medicine.disease Gastrostomy Surgery Oropharyngeal Neoplasms Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell business Chemoradiotherapy |
| Zdroj: | HeadneckREFERENCES. 43(10) |
| ISSN: | 1097-0347 |
| Popis: | Background Patients with human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) continue to experience disappointing outcomes following chemoradiotherapy (CRT) and appreciable morbidity following historical surgical approaches. We aimed to investigate the oncologic outcomes and perioperative morbidity of a transoral robotic surgery (TORS) approach to surgically resectable HPV-negative OPSCC. Methods Retrospective analysis HPV-negative OPSCC patients who underwent TORS, neck dissection and pathology-guided adjuvant therapy (2005-2017). Results Fifty-six patients (91.1% stage III/IV) were included. Three-year overall survival, locoregional control, and disease-free survival were 85.5%, 84.4%, and 73.6%, respectively (median follow-up 30.6 months, interquartile range 18.4-66.6). Eighteen (32.1%) patients underwent adjuvant radiotherapy and 20 (39.3%) underwent adjuvant CRT. Perioperative mortality occurred in one (1.8%) patient and hemorrhage occurred in two (3.6%) patients. Long-term gastrostomy and tracheostomy rates were 5.4% and 0.0%, respectively. Conclusion The TORS approach for resectable HPV-negative OPSCC can achieve encouraging oncologic outcomes with infrequent morbidity. |
| Databáze: | OpenAIRE |
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