A limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genitalChlamydia muridarumchallenge
| Autor: | Guangming Zhong, Janakiram Seshu, Bharat Kumar Reddy Chaganty, Bernard P. Arulanandam, James P. Chambers, Weidang Li, M. Neal Guentzel, Ashlesh K. Murthy |
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| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Chlamydia muridarum Immunology Colony Count Microbial Biology Microbiology Article Mice Adjuvants Immunologic Immunity medicine Animals Immunology and Allergy Chlamydiaceae Antigens Bacterial Vaccines Synthetic Chlamydia General Medicine Chlamydia Infections biology.organism_classification medicine.disease Antibodies Bacterial Virology Vaccination Bacterial vaccine Infectious Diseases Oligodeoxyribonucleotides Immunization Bacterial Vaccines biology.protein Female Antibody Genital Diseases Female |
| Zdroj: | FEMS Immunology & Medical Microbiology. 55:271-279 |
| ISSN: | 1574-695X 0928-8244 |
| DOI: | 10.1111/j.1574-695x.2008.00517.x |
| Popis: | Mice deficient in B cells (micromT mice) were used to evaluate the role of antibody in enhanced chlamydial clearance and reduction of pathology afforded by vaccination with recombinant chlamydial protease-like activity factor (rCPAF). Enhanced, but comparable, chlamydial clearance was observed in micromT and wild-type (WT) mice after rCPAF+CpG vaccination. Chlamydia-induced pathology was present in mock-immunized animals, but at significantly greater levels in micromT than WT mice, whereas vaccinated micromT and WT mice exhibited similar reductions in pathology. Thus, antibodies may play a role in protection against chlamydial pathology after primary infection, but were largely dispensable in rCPAF+CpG-induced chlamydial clearance and reduction in pathology. |
| Databáze: | OpenAIRE |
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