Nitric oxide donors, sodium nitroprusside and S-nitroso-N-acetylpenicillamine, stimulate myoblast proliferation in vitro
| Autor: | T. M. Best, J. A. Ulibarri, P. E. Mozdziak, E. Schultz, C. Cook |
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| Rok vydání: | 1999 |
| Předmět: |
Nitroprusside
Turkeys Myoblast proliferation Sodium chemistry.chemical_element S-Nitroso-N-Acetylpenicillamine Pharmacology Nitric Oxide Nitric oxide chemistry.chemical_compound medicine Animals Nitric Oxide Donors Muscle Skeletal Cells Cultured Chemistry Penicillamine Snap Cell Biology General Medicine musculoskeletal system Biochemistry Cell culture Sodium nitroprusside S-Nitroso-N-acetylpenicillamine Cell Division Intracellular Developmental Biology medicine.drug |
| Zdroj: | In Vitro Cellular & Developmental Biology - Animal. 35:215-218 |
| ISSN: | 1543-706X 1071-2690 |
| DOI: | 10.1007/s11626-999-0029-1 |
| Popis: | Nitric oxide (NO) is an inter- and intracellular messenger involved in a variety of physiologic and pathophysiologic conditions. The effect of two NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) and their effect on myoblast proliferation was examined. Both donors stimulated an increase in myoblast cell number over a range (1-10 microM) of donor concentrations. However, 50 microM SNAP inhibited myoblast proliferation. Cell numbers from cultures treated with degraded 10 microM SNAP were equivalent to the control. Therefore, it appears NO can stimulate as well as inhibit myoblast proliferation. |
| Databáze: | OpenAIRE |
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