A Seven-Years Experience in Treatment of Childhood all in Bulgaria
| Autor: | Ivan I. Kirov, V L Spassov, E. Koleva, M. Sarbinova, M. Jordanova, I. Kalev, L. Mendizova, G. Michailov, D. Konstantinov, Bobev D |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Treatment protocol Adolescent Disease-Free Survival Recurrence Standard Risk Acute lymphocytic leukemia Antineoplastic Combined Chemotherapy Protocols medicine Humans Bulgaria Child Childhood all Survival analysis business.industry Remission Induction Event free survival Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Oncology El Niño Child Preschool Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Pediatric Hematology and Oncology. 15:157-164 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.3109/08880019809167230 |
| Popis: | After analyzing nonsatisfactory therapeutic results in the 1970s and early 1980s, the 81-01 treatment protocol of the Dana-Farber Cancer Institute was initiated in 1987 in the Children's Oncohaematology Clinic in Sofia, Bulgaria. Two hundred thirty patients were enrolled with a period of observation of a minimum of 14 and a maximum of 97 months; the median age was 5.83 +/- 3.6 years. According to the original criteria, standard risk (SR) patients were 38.26% and high-risk (HR) patients 61.74%. The probability for event-free survival at the seventh year estimated with the Kaplan-Meier method for the total group was 0.67 +/- 0.04 (+/- SE) and 0.55 +/- 0.09 and 0.81 +/- 0.06 for HR and SR, respectively (P.001). Improvement of therapeutic results in terms of remission failures, early deaths, patients lost to follow-up, and rate of relapses is discussed. |
| Databáze: | OpenAIRE |
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